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After neurotransmitters are synthesized, they are packaged and stored in vesicles.These vesicles are pooled together in terminal boutons of the presynaptic neuron.The undershoot phase occurs because unlike voltage-gated sodium channels, voltage-gated potassium channels inactivate much more slowly.Nevertheless, as more voltage-gated K channels become inactivated, the membrane potential recovers to its normal resting steady state..

Although slower than ionotropic receptors that function as on-and-off switches, metabotropic receptors have the advantage of changing the cell's responsiveness to ions and other metabolites, examples being gamma amino-butyric acid (inhibitory transmitter), glutamic acid (excitatory transmitter), dopamine, norepinephrine, epinephrine, melanin, serotonin, melatonin, and substance P.

Neurons are diverse with respect to morphology and function.

Thus, not all neurons correspond to the stereotypical motor neuron with dendrites and myelinated axons that conduct action potentials.

As Na ions enter the cell, the membrane potential is further depolarized, and more voltage-gated sodium channels are activated.

Such a process is also known as a positive feedback loop.

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Plastic change often results from the alteration of the number of neurotransmitter receptors located on a synapse.